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大肠直肠癌中的代谢重编程和免疫性:机制和治疗影响

Jun Zhu¹, Kuan Shen^2,3, Qiang Su⁴

¹Department of Gastroenterology, Taizhou Second People's Hospital Affiliated to Yangzhou University, Taizhou, Jiangsu, China.

Frontiers in cell and developmental biology

|August 29, 2025

概括

代谢重编程和免疫发生导致结直肠癌 (CRC) 的进展和治疗耐药性. 了解这些过程为精确的CRC治疗提供了新的治疗目标.

科学领域:

癌症学
癌症免疫学
代谢途径

背景情况:

结肠直肠癌 (CRC) 的全球发病率和死亡率很高.
代谢重编程和免疫发生在CRC瘤发生,进展和治疗耐药性方面至关重要.
这些机制影响瘤微环境 (TME) 和免疫细胞功能.

研究的目的:

系统地审查目前关于CRC代谢重编程和免疫的研究.
探索基于这些机制的有针对性的治疗策略.
为精确的CRC治疗提供一个新的理论框架.

主要方法:

在CRC中对代谢重编程的系统文献审查.
在结直肠瘤中分析免疫性特征.
对新兴的CRC向治疗方法的审查.

主要成果:

代谢重编程为CRC细胞提供燃料并调节TME.
免疫发生会降低抗瘤免疫力,并促进免疫逃生.
代谢和免疫的联合失调导致CRC的进展和抵抗.

结论:

在CRC发育过程中,代谢重编程和免疫发生是相互交织的.
针对这些途径为CRC治疗提供了有前途的途径.
进一步的研究可以完善结直肠癌的精确治疗策略.

关键词:

大肠直肠癌免疫发生免疫疗法代谢重编程瘤微环境

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