对青光眼神经营养因子的研究:全球文献分析
Sahilah Ermawati1, Winastari Yarhanim Triniputri2, Muhana Fawwazy Ilyas2,3,4
1Department of Ophthalmology, Faculty of Medicine, Universitas Muhammadiyah Surakarta, Surakarta 57162, Central Java, Indonesia.
International journal of ophthalmology
|August 29, 2025
概括
这项研究分析了关于青光眼治疗神经营养因子的780篇文章,揭示了研究趋势和未来方向. 关键领域包括神经保护,眼部药物输送和干细胞治疗.
科学领域:
- 眼科 眼科
- 神经科学
- 药理学
背景情况:
- 眼是导致不可逆转失明的主要原因.
- 神经营养不良因素为青光眼的神经保护提供了潜在的治疗点.
- 目前的研究趋势需要有系统的分析来指导未来的调查.
研究的目的:
- 综合性地研究眼镜治疗中神经营养因子的现状.
- 确定这一领域的新兴研究热点和未来方向.
主要方法:
- 在Scopus上进行了系统的文献搜索,获取了918篇文章.
- 在分析中包括了1989年至2023年间发表的780篇文章.
- 使用Google Sheets,Biblioshiny和VosViewer进行了图书识别分析和可视化.
主要成果:
- 全球出版物产量呈现显著上升趋势,预计将持续下去.
- 美国,中国和日本是主要的贡献者.
- 研究重点已经从特定的分子 (谷氨酸,CNTF,GDNF) 演变为视神经损伤,主要集中在神经保护,药物输送和干细胞治疗方面.
结论:
- 这篇综述阐明了当前关于青光眼治疗中神经营养因子的研究.
- 未来的研究应该探索神经生理机制,先进的眼部药物输送,以及特定的神经营养因子的临床效用.
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