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监测与化疗相关的心脏毒性高风险患者:回顾性分析
Arnold Méndez-Toro1, Felipe Alejandro Muñoz-Rossi2, Rafael Enrique Tejada-Cabrera2
1Department of Cardiology, Hospital Universitario Nacional de Colombia, Bogotá 111321, Colombia. arnold.mendez@hun.edu.co.
World journal of clinical cases
|August 29, 2025
概括
这项研究表明心声学和生物标志物可以检测癌症患者的化疗引起的心脏毒性. 早期诊断和治疗需要标准化方案,以改善患者的治疗结果.
科学领域:
- 心脏病学
- 癌症学
- 医疗诊断
背景情况:
- 癌症发病率是一个全球性的健康挑战, 化疗提供生存效益但带来心脏毒性风险.
- 化学疗法的心血管并发症显著影响患者的发病率和死亡率.
- 早期发现心脏毒性对于及时干预和保持心脏功能至关重要.
研究的目的:
- 对接受高风险化疗的癌症患者进行心脏毒性监测的诊断工具的有效性进行评估.
- 评估生物标志物和心声回声仪在鉴定化疗引起的心脏损伤时的使用.
主要方法:
- 在哥伦比亚国家大学医院进行了一项观察性回顾性队列研究 (2016-2019).
- 包括的患者 (≥18岁) 接受了潜在的心脏毒性化疗.
- 通过左心室喷射分数 (LVEF) 和异常生物标志物来定义心脏毒性,数据被描述性地分析.
主要成果:
- 在分析的195名患者中,8. 7%出现心脏毒性,大多数是轻微的.
- 在治疗后观察到LVEF中位数 (62%至46%) 和纵向STRAIN值显著下降.
- 在58. 8%的心脏毒性病例中使用托洛,而使用ProBNP则有限 (17. 6%).
结论:
- 对瘤患者的心脏毒性评估有价值.
- 标准化方案对于优化化疗引起的心脏毒性的早期诊断和管理至关重要.
- 该研究的回顾性设计和有限的生物标志物利用可能会影响概括性.
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