Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

332
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
332
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.1K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

1.8K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
1.8K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

77
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
77
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

33
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
33
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

213
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
213

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

CDK4/6 inhibition induces a senescence-associated secretory phenotype via delayed NF-κB activation.

Life science alliance·2026
Same author

Hyperactive BMP and Mechanosignaling Remodel Chromatin to Drive Aberrant Osteogenesis in FOP.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Glucose-6-phosphate dehydrogenase variants modify 3D genomic organization to suppress maladaptive gene expression and vascular disease.

The Journal of biological chemistry·2026
Same author

Engineering a Matrix-Preserving Vascular dECM Platform with Tunable Stiffness for <i>In Vitro</i> Vascular Remodeling.

bioRxiv : the preprint server for biology·2026
Same author

ARHGAP18 complexes with both YAP and Merlin and is required for basal actin bundles.

Molecular biology of the cell·2026
Same author

Mechanotherapeutic Potential of Survivin in Glioblastoma.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Sep 9, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K

转录和多尺度网络分析揭示了心血管疾病的主要驱动因素

Bat-Ider Tumenbayar1, Khanh Pham2, John C Biber2

  • 1Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY 14203 USA; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.

IEEE transactions on molecular, biological, and multi-scale communications
|August 29, 2025
PubMed
概括

在小鼠中,血管损伤会引发类似于心血管疾病的分子变化. 这项研究验证了用于调查心血管疾病的细线损伤模型,揭示了基因表达,蛋白质网络和疾病途径之间的联系.

关键词:
动蛋白细胞骨架动脉硬性欧洲货币市场全基因组分析机械生物学分子通信

更多相关视频

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
09:45

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

3.0K
Isolation of Endothelial Cells from the Lumen of Mouse Carotid Arteries for Single-Cell Multi-Omics Experiments
09:12

Isolation of Endothelial Cells from the Lumen of Mouse Carotid Arteries for Single-Cell Multi-Omics Experiments

Published on: October 4, 2021

3.4K

相关实验视频

Last Updated: Sep 9, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K
Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
09:45

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

3.0K
Isolation of Endothelial Cells from the Lumen of Mouse Carotid Arteries for Single-Cell Multi-Omics Experiments
09:12

Isolation of Endothelial Cells from the Lumen of Mouse Carotid Arteries for Single-Cell Multi-Omics Experiments

Published on: October 4, 2021

3.4K

科学领域:

  • 分子生物学
  • 生物信息学
  • 心血管研究

背景情况:

  • 心血管疾病 (CVD) 涉及分子信号,细胞变化和细胞外基质 (ECM) 改变.
  • 细线血管损伤模型,通常用于增生,被探索其对心血管疾病的相关性.

研究的目的:

  • 测试血管损伤在转录和蛋白质水平上诱导心血管疾病的假设.
  • 评估细线血管损伤模型适用于心血管疾病研究.

主要方法:

  • 从受伤和未受伤的小鼠大腿动脉中分析微阵列数据集.
  • 用机器学习分析疾病途径构建和分析蛋白质-蛋白质相互作用网络.

主要成果:

  • 鉴定了1467个与心血管疾病 (如动脉样硬化和心律失常) 相关的基因.
  • 发现了ECM,细胞骨和免疫反应集群之间的显著分子通信.
  • 相关的ECM重塑和免疫反应交叉对主动脉动脉瘤和功能衰竭.

结论:

  • 血管损伤模型有效地引起了与心血管疾病相关的转录和分子网络变化.
  • 这种模型通过模拟与疾病相关的分子事件来促进心血管疾病研究.