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单细胞和空间转录组的综合分析显示,头癌的淋巴结中通过脂肪酸代谢介导的转移机制

Jinru Weng^1,2, Jiajie Mao³, Yixing Li¹

¹College of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China.

Frontiers in immunology

|August 29, 2025

概括

脂肪酸代谢,特别是涉及LGALS1,驱动了头部和部状细胞癌 (HNSCC) 的转移. 抑制LGALS1可以减少HNSCC细胞的增殖和转移,从而提供潜在的治疗点.

科学领域:

癌症学
分子生物学
代谢过程

背景情况:

头部和部状细胞癌 (HNSCC) 是一种常见的恶性瘤.
瘤复发和转移显著影响HNSCC患者的预后.

研究的目的:

研究导致HNSCC转移的进化机制.
探索脂肪酸代谢在HNSCC传播中的作用.

主要方法:

使用单细胞RNA测序 (scRNA-seq) 和空间转录组 (ST) 数据.
进行伪时序,分化,细胞相互作用和通路分析.
进行了体内和体外实验来评估LGALS1的功能.

主要成果:

确定了三个子集群:原发性,过渡性和转移性瘤.
在瘤发育过程中观察到脂肪酸代谢升高,与LGALS1相关.
证实LGALS1抑制了HNSCC的扩散,迁移和淋巴结转移.

结论:

在HNSCC传播过程中,代谢变化,特别是脂肪酸代谢变化至关重要.
转移性瘤通过脂肪酸代谢调节在HNSCC转移机制中发挥关键作用.
作为HNSCC转移的关键调节剂,LGALS1是潜在的治疗点.

关键词:

在LGALS1 脂肪酸代谢发生转移单细胞RNA测序空间转录组

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