在未接种疫苗的患者中,促炎和抗炎细胞因子多态与COVID-19严重性的关联
Laura E Martínez-Gómez1, Carla I Oropeza-Vélez2, Maylin Almonte-Becerril3
1Laboratorio de Gerociencias, Dirección General, Departamento de Reconstrucción Articular, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Secretaría de Salud, Mexico City, Mexico.
Frontiers in immunology
|August 29, 2025
概括
细胞因子如TNF-α,IL-6,IL-10和CCL5的遗传变异会影响COVID-19的严重程度. 在未接种疫苗的患者中,特定的多态性与严重疾病和死亡的风险增加有关.
科学领域:
- 免疫遗传学
- 病毒学
- 分子流行病学
背景情况:
- 细胞因子和化学因子对于对SARS-CoV-2的免疫反应至关重要.
- 这些分子中的基因变异可以显著影响疾病的结果.
- 了解这些遗传关联是预测COVID-19严重性的关键.
研究的目的:
- 调查TNF-α,IL-6,IL-8,IL-10和CCL5基因与COVID-19严重性之间的关系.
- 在未接种疫苗的患者中评估特定基因变异与临床结果之间的关系.
主要方法:
- 根据世卫组织疾病严重程度分类的627名未接种疫苗的COVID-19患者的横截面研究.
- 血清中细胞因子和化学因子水平的评估 (IFN-α,IFN-γ,TNF-α,IL-1Ra,IL-2,IL-6,IL-7,IL-10,CCL2,CCL3,CXCL8,CXCL10,GCSF).
- 克鲁斯卡尔-瓦利斯测试用于组比较和物流回归的多态性-严重性关联.
主要成果:
- 在已故患者中观察到IL-2,IL-6和CCL-2水平升高.
- 与轻度感染者相比,中度感染者群体的IL-10水平较高.
- 五种多态性 (TNF-α rs1800610,IL-6 rs1800796,IL-10 rs1800871/rs1800872,CCL5 rs3817656) 与严重的COVID-19风险增加有关.
结论:
- 一种特定的TNFα基因变异 (rs1800629) 似乎可以防止中度/严重的COVID-19和相关的细胞因子失调.
- 在IL-10 (rs1800872,rs1800871) 和CCL-5 (rs2107538) 中的多态性与死亡风险增加有关.
- CCL-5 的小等位基因与化学激素水平升高和细胞激素风暴标志物有关.
相关概念视频
01:05Single Nucleotide Polymorphisms-SNPs
15.8K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.8K
01:26Factors Affecting the Risk of Infection
12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
01:20The JAK-STAT Signaling Pathway
9.2K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.2K
01:20COPD: Pathogenesis and Clinical Features
516
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
516
01:27Psychoneuroimmunology: Cardiovascular Disease
77
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
77
01:38Inflammation
55.1K
Overview
55.1K