在膀癌患者中预测静脉血栓塞的C-反应蛋白和D-二次蛋白升高
Bo Chen1,2, Tonghe Zhang1,2, Yisong Wang1,2
1Department of Vascular Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China.
Frontiers in immunology
|August 29, 2025
概括
在膀癌 (BC) 患者中,高C反应蛋白 (CRP) 和D- 模体 (D- D) 预测静脉血栓塞栓症 (VTE) 风险. 结合CRP和D-D可以提高预测准确度,特别是在非感染个体中.
科学领域:
- 癌症学
- 血液学
- 临床医学
背景情况:
- 住院膀癌患者面临静脉血栓塞栓症 (VTE) 的重大风险.
- 准确预测VTE对于有效的临床治疗和预防策略至关重要.
研究的目的:
- 评估C反应蛋白 (CRP) 作为入院BC患者的静脉突发症预测因子.
- 评估CRP和D-dimer (D-D) 在BC中对静脉瘤风险的联合预测值.
- 在BC指导临床预防和治疗策略.
主要方法:
- 对2,164名入院BC患者的临床数据进行了回顾性分析.
- 病例对照研究设计,包括52例VTE病例和104例匹配对照.
- 使用了条件后勤回归,ROC曲线分析和分层分析.
主要成果:
- 在BC患者中,CRP和D-D水平的升高与静脉瘤风险的增加显著相关.
- 与单独使用CRP (AUC=0. 734) 或D- D (AUC=0. 817) 相比,联合CRP和D- D模型的预测性能更好.
- 感染状况影响了CRP和DD的预测值,未感染患者的预测值可能更高.
结论:
- 在BC患者中,CRP和D-D水平升高是静脉瘤的潜在指标.
- 结合CRP和DD可以提高静脉瘤风险预测的准确性.
- 这些标志物的预测效用可能因患者的感染状况而异.
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