相关实验视频

Updated: Sep 9, 2025

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue

Published on: February 3, 2023

对肝细胞癌外体的多维洞察:从起源到临床应用

Xiang Zhang¹, Cheng Zhang², Zheng Zhang³

¹School of Anesthesiology, Wannan Medical College, Wuhu, Anhui, China.

Frontiers in immunology

|August 29, 2025

概括

外体是肝细胞癌 (HCC) 进展的关键因素,驱动药物耐药性和转移. 工程外体具有针对性肝癌治疗的潜力,但临床应用仍然存在挑战.

科学领域:

癌症学
细胞生物学
纳米医学

背景情况:

肝细胞癌 (HCC) 是一种由瘤微环境 (TME) 影响的致命癌症.
外体,纳米级囊泡,对于TME内的细胞间通信至关重要.
外体细胞有助于HCC的发病,进展,转移和免疫逃避.

研究的目的:

审查外体在HCC发育和进展中的多方面的作用.
探索工程外体在HCC治疗中的潜力.
确定基于外体的HCC研究的挑战和未来方向.

主要方法:

对HCC中的外体功能进行文献综述.
在TME中对外体介导细胞间通信的分析.
用于治疗应用的工程外体的评估.

主要成果:

通过重塑TME,外体促进HCC的发作,耐药性和转移.
外基因组调节免疫反应,为瘤免疫逃避创造一个免疫抑制环境.
工程外体对向药物输送和癌症治疗具有前景.

结论:

外体是HCC病变的核心,并代表治疗点.
工程外基因组为精确的肝癌治疗提供了一个有前途的策略.
需要进一步的研究来克服外体隔离,标准化和临床验证方面的挑战.

关键词:

药物耐受性外基因组肝细胞癌 (HCC)发生转移针对性的治疗瘤微环境 (TME)

更多相关视频

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile

Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile

Published on: June 13, 2016

相关概念视频

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...