便秘与中风风险之间的关联:系统审查和元分析
Feng Tang1, Tianjun Zhao2, Peiwen Dong1
1Department of Gastroenterology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, China.
Frontiers in neurology
|August 29, 2025
概括
便秘会使整体中风风险增加23%. 这项分析发现便秘是缺血性中风的重要危险因素,
科学领域:
- 神经学
- 胃肠病学
- 公共卫生
背景情况:
- 便秘是一种常见的疾病,
- 了解它与脑血管事件的关联对于预防策略至关重要.
研究的目的:
- 系统地审查和对便秘与中风风险之间的关联进行元分析.
- 探索这种关联在中风亚型 (缺血和出血) 中的潜在差异.
主要方法:
- 在PubMed,科学网和Cochrane图书馆进行了全面的搜索.
- 包含的研究报告了便患者中风的调整后的效果估计 (OR,HR,RR).
- 使用随机效应模型进行元分析,对中风类型,区域,研究设计和性别进行分组分析.
主要成果:
- 分析了超过69万参与者的13项研究.
- 便秘与整体中风风险增加23%有关 (OR=1.23,95% CI:1. 10-1. 36).
- 这种关联在缺血性中风 (OR=1. 39,95% CI: 1. 19-1. 60) 中是显著的,但在出血性中风 (OR=1. 03,95% CI: 0. 80-1. 26) 中并非显著. 没有观察到女性的风险增加.
结论:
- 便秘被认为是缺血性中风的危险因素.
- 这些发现凸显了便秘是治疗缺血性中风的潜在因素.
- 需要进一步研究机制和干预措施.
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