重复电疗法对急性压力的生理和行为反应的影响:双盲随机临床试验
Kana Okano1, Marissa Marko Lee1, Hannah Hart-Pomerantz1
1Center for Applied Brain and Cognitive Sciences, Tufts University, Medford, MA, United States.
Frontiers in human neuroscience
|August 29, 2025
概括
大脑电疗刺激 (CES) 在健康个体中没有显著降低应激反应. 这种神经调节技术在缓解急性压力方面表现出有限的有效性,这挑战了其广泛用于缓解焦虑的应用.
科学领域:
- 神经科学
- 心理生理学
- 临床试验
背景情况:
- 电疗刺激 (CES) 是一种用于减轻压力和焦虑的神经调节技术.
- 目前关于CES疗效的证据是混合的,使用严格控制和重复暴露的研究有限.
研究的目的:
- 调查重复的CES会话是否可以减轻对急性实验室压力的生理,生化,认知和情感反应.
主要方法:
- 一个双盲,随机,安慰剂对照试验,包括46名健康参与者 (军人和平民).
- 参与者在四周内接受了20次活动性CES或假刺激.
- 测量包括急性压力诱导前后的生理,生化,认知和情感指数.
主要成果:
- 压力诱导有效增加了交感上腺 (SAM) 和下丘脑上腺 (HPA) 标志物和焦虑.
- 与假刺激相比,活动性CES在大多数结果中没有显著差异.
- 在压力恢复,焦虑或认知表现方面没有发现有意义的群体差异.
结论:
- 没有结果表明CES在缓冲健康个体的急性应激反应中的有效性有限.
- 目前的结果挑战了现有的CES机制理论.
- 需要进行进一步的受控试验,以探索不同参数,种群和神经生理终点的CES潜力.
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