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Updated: Sep 9, 2025

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TNG260是一种小分子CoREST抑制剂,可使STK11突变瘤对抗PD-1免疫疗法产生敏感性

Leanne G Ahronian1, Soumyadip Sahu2, Minjie Zhang3

  • 1Tango Therapeutics (United States), Boston, MA, United States.

Cancer research
|August 29, 2025
PubMed
概括

具有STK11突变的非小细胞肺癌 (NSCLC) 对抗PD-1治疗具有抗药性. 在临床前和临床研究中,用TNG260向HDAC1可以逆转这种抗药性,从而增强抗PD-1的疗效.

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