多学科干预对患有慢性疲劳的淋巴瘤幸存者的疲劳的影响:随机对照试验方案 (REFUEL)
Synne-Kristin Hoffart Bøhn1, Kristin V Reinertsen1, Cecilie E Kiserud1
1Department of Oncology, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway.
JMIR research protocols
|August 29, 2025
概括
这项研究研究了对淋巴瘤幸存者的慢性疲劳 (CF) 的多学科干预. REFUEL试验旨在减少疲劳并改善生活质量,为这一患者群提供新的证据.
科学领域:
- 癌症学
- 临床试验
- 康复工作
背景情况:
- 慢性疲劳 (CF) 在治疗后对25-40%的淋巴瘤幸存者产生重大影响.
- 缺乏针对CF幸存者的随机对照试验 (RCT).
- REFUEL试验通过评估一种新的多学科方法来弥补这一缺口.
研究的目的:
- 评估12周多学科干预对CF淋巴瘤幸存者的疲劳水平的影响.
- 评估二次结果,包括与健康相关的生活质量 (HRQoL),身体健康和成本效益.
- 探讨长期利益,自我管理策略,以及对幸存者的伴侣和工作与生活平衡的影响.
主要方法:
- 一个双臂随机对照试验 (RCT) 涉及150名CF淋巴瘤幸存者.
- 干预组接受了患者教育,体育炼,认知行为治疗和营养咨询.
- 对照组接受了通常的护理. 通过查尔德疲劳问卷测量疲劳;通过验证问卷测量HRQoL和其他结果;通过运动测试测量适应性.
主要成果:
- 在2021年12月至2023年3月期间招募了150名幸存者.
- 三个月的随机化后评估在2023年6月完成.
- 计划在2025年6月之前完成为期两年的后续评估.
结论:
- 预计REFUEL试验将提供关于CF多学科干预在淋巴瘤幸存者的有效性的关键证据.
- 这些发现将为临床实践提供信息,并改善长期疲劳的幸存者.
- 这项研究将为改善这一群体的HRQoL和整体幸福感提供见解.
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