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在马群中细分的黄状阿隆山病毒的血清流行

Saskia Janshoff¹, Ricarda Plümers², Anna Sophie Ramsauer³

¹Department of Molecular and Medical Virology, Ruhr University Bochum, Germany; Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Germany; Department for Translational and Computational Infection Research, Ruhr University Bochum, Bochum, Germany.

Veterinary microbiology

|August 29, 2025

概括

龙山病毒 (ALSV) 具有广泛的地理分布,在多个大陆的马中发现了高抗体患病率. 马是监测这种新兴的病原体的关键哨兵.

科学领域:

兽医病毒学
新出现的传染病
一个健康

背景情况:

新兴的病原体带来全球健康风险, 环境和社会变化加剧了这种风险.
是重要的传播者,增加了传播疾病的发病率.
龙山病毒 (ALSV) 是一种类似于黄的病毒,于2017年首次在人类中被发现,其天然宿主和传播方式尚不清楚.

研究的目的:

调查马群中ALSV的流行和地理分布.
评估马匹作为ALSV监测的哨戒动物的潜力.
了解ALSV暴露的传播和潜在风险.

主要方法:

来自美洲,欧洲和大洋洲的商业马类血清池对抗ALSV抗体的分析.
在德国对473匹纯种马进行了抗体检测.
在5年内对124匹马进行长度抗体水平监测.

主要成果:

在13个国际血清池中检测到12个抗ALSV抗体,表明分布广泛.
87.1%的德国马对ALSV抗体呈阳性,老年马的比例更高.
在一项纵向研究中,71. 77%的马在某个时刻表现出阳性抗体状态,证明了动态暴露.

结论:

在不同地区的马群体中,ALSV抗体的流行率很高,这表明经常接触.
马是监测传播的病原体如ALSV的有价值的哨兵模型.
需要进一步研究以澄清ALSV的传播及其对人类和动物健康的风险.

关键词:

龙山病毒马类动物纵向跟踪细分的状病毒血清学传播的病毒

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