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计算机辅助设计以提高 ω-胺转氨酶对甲醇作为辅溶剂的耐受性

Shuai Qiu1, Tong Wang1, Cong-Lin Ju1

  • 1Key Laboratory of Chemical and Biological Processing Technology for Farm Products of Zhejiang Province, Zhejiang Provincial Collaborative Innovation Center of Agricultural Biological Resources Biochemical Manufacturing, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.

Bioorganic chemistry
|August 29, 2025
PubMed
概括

在甲醇中改造的Aspergillus terreus ω-胺转氨酶 (AtATA) 的活性和稳定性得到了提高. 这种改进的酶对于工业生物技术中高效的 (R) - 基拉胺生产至关重要.

关键词:
氨酸计算机辅助设计有机辅溶剂的耐受性胺转胺酶

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