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  3. 接近红外发射的持续发光成像引导的基因/光热协同疗法用于增强瘤细胞损伤
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  3. 接近红外发射的持续发光成像引导的基因/光热协同疗法用于增强瘤细胞损伤

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接近红外发射的持续发光成像引导的基因/光热协同疗法用于增强瘤细胞损伤

Xinwei Yun1, Guoqing Feng2, Mengxi Zhu3

  • 1Department of Thyroid and Neck Tumor, Tianjin Medical University, Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Tianjin 300060, China.

Journal of colloid and interface science
|August 29, 2025

在PubMed 上查看摘要

概括
此摘要是机器生成的。

这项研究引入了用于先进癌症治疗的近红外纳米粒子. 这种纳米平台结合了基因疗法和光热治疗,

关键词:
基因治疗在近红外光学成像持续发光的光热疗法

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科学领域:

  • 生物医学工程
  • 纳米技术
  • 癌症学

背景情况:

  • 传统的光导向癌症疗法受到高背景噪音的影响,限制了临床使用.
  • 近红外 (NIR) 发射的持续发光纳米粒子提供了诸如无现场激发,高信号噪声比和深层组织透等优势.

研究的目的:

  • 开发一个创新的纳米平台以成像为导向的组合疗法.
  • 使用多功能纳米平台实现有效的瘤细胞根除.

主要方法:

  • 通过将Bax基因和绿素 (ICG) 加载到由ZnGa2O4:Cr3+ (ZGC) 封装的半孔纳米粒子,开发了一个纳米平台.
  • 使用纳米平台同时进行NIR持久发光成像和对小鼠的协同治疗.

主要成果:

  • 该纳米平台展示了同时进行NIR持久发光成像和协同癌症治疗.
  • 通过808nm NIR激光照射的组合基因疗法和光热治疗实现了固体瘤的有效抑制.

结论:

  • 开发的纳米平台显示出多模式治疗平台的潜力.
  • 启用持续发光成像指导的瘤视觉治疗,导致高效的瘤细胞根除.