1990-2021年阿拉伯国家肝细胞癌的变化概况和负担
Ziyan Pan1, Abdulla Al Hassani2, Mona H Ismail3
1Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, NSW, Australia.
Annals of hepatology
|August 29, 2025
概括
阿拉伯国家的肝细胞癌正在从病毒性肝炎转变为与代谢功能障碍相关的脂肪肝疾病 (MAFLD). 公共卫生战略必须应对这些不断变化的风险因素, 以应对日益严重的肝癌.
科学领域:
- 肝病学
- 流行病学
- 公共卫生
背景情况:
- 肝细胞癌 (HCC) 在阿拉伯国家是一个重大的健康挑战.
- 近几十年来,该地区的HCC病因和流行病学发生了显著的变化.
研究的目的:
- 评估22个阿拉伯国家的HCC负担和形象的变化.
- 分析1990年至2021年的趋势,重点关注病因学和流行病学.
主要方法:
- 对22个阿拉伯国家的2021年全球疾病负担 (GBD) 数据分析.
- 对HCC发病率,流行率,死亡率和DALYs的年龄标准化率 (ASR) 和估计年百分比变化 (EAPC) 的提取.
- 数据按病因和性别分层.
主要成果:
- 在2021年,毛里塔尼亚和埃及的HCC患病率最高,超过全球平均水平.
- 在该地区,与MAFLD相关的HCC病例呈上升趋势,阿曼,埃及和卡塔尔的病例显著增加.
- 病毒性肝炎相关的HCC下降,而HCC死亡率在毛里塔尼亚和埃及仍然最高. 性别差异的发病率持续存在,但随着时间的推移而缩小,女性HCC发病率与MAFLD相关的病例增加得更快.
结论:
- 阿拉伯地区面临着不断变化的HCC负担,从病毒性肝炎转向MAFLD作为主要驱动因素.
- 需要紧急的公共卫生干预措施.
- 策略应侧重于针对代谢风险因素,并继续努力消除病毒性肝炎,以减轻未来的HCC增加.
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