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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Tissue Renewal without Stem Cells01:23

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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相关实验视频

Updated: Sep 9, 2025

Minimally Invasive Muscle Embedding MIME - A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis
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机械疗法:调节组织再生和纤维化的免疫细胞功能

Niamh A Ward1, Hannah Prendeville1, Eimear J Wallace2

  • 1Biomedical Engineering, School of Engineering, College of Science and Engineering, University of Galway, Galway, Ireland.

Acta biomaterialia
|August 29, 2025
PubMed
概括

通过调节免疫细胞, 机械疗法利用机械力量改善愈合并减少纤维化. 了解机械负荷如何影响免疫反应是优化这种治疗组织再生的关键.

关键词:
纤维化/外体反应免疫反应机械治疗医疗植入物组织再生

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Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
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相关实验视频

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Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
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科学领域:

  • 生物医学工程
  • 复原医学
  • 免疫学

背景情况:

  • 在再生医学和药物输送方面, 机械疗法是以机械力量为治疗目的.
  • 在体内改善肌肉再生和调节纤维化的有效性已被证明.
  • 然而,潜在的细胞机制,特别是免疫细胞对机械负荷的反应,需要进一步阐明.

研究的目的:

  • 审查关于肌肉损伤和医疗植入物的临床前发现.
  • 讨论免疫细胞的机械敏感性及其在机械压力下的信号通路.
  • 探索机械治疗,免疫调节和组织再生中的纤维化之间的关系.

主要方法:

  • 对机械治疗应用的临床前研究的审查.
  • 讨论免疫细胞机械敏感性和信号通路.
  • 分析机械负荷参数对组织愈合和纤维化的影响.

主要成果:

  • 机械疗法可以改善功能性肌肉再生和调节纤维化.
  • 免疫细胞对机械负荷的反应是复杂的,取决于大小,频率和持续时间等参数.
  • 了解这些免疫反应对于有效的机械疗法设计至关重要.

结论:

  • 机械疗法提供了一个有前途的方法来调节免疫反应并改善再生结果,特别是在预防纤维化方面.
  • 需要进一步的研究,以充分理解和优化机械刺激的参数,以获得治疗效益.
  • 开发机械治疗设备需要解决控制机械负荷和向特定免疫通路的挑战.