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选择性动脉支架的药物反应测试:阿司匹林和克洛皮多格勒不响应的发生率以及对干预后脑缺血的影响

Farzaneh Yousefi1, Dimah Hasan1, Frederic De Beukelaer1

  • 1Department of Neuroradiology, University Hospital RWTH Aachen, Aachen, Germany.

The neuroradiology journal
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PubMed
概括

在接受动脉支架 (CAS) 的患者中,抗血小板不响应克洛皮多格勒 (CPG) 和阿司匹林 (ASS) 是常见的. 然而,在CAS期间使用提洛菲班可以消除对手术后脑梗塞无反应的影响.

关键词:
冠状动脉支架急性缺血性中风抗阿司匹林的情况克洛皮多格勒耐药性

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科学领域:

  • 心脏病学
  • 神经学
  • 药理学

背景情况:

  • 在接受动脉支架 (CAS) 的患者中,克洛皮多格勒 (CPG) 和阿司匹林 (ASS) 的不响应的患病率尚不清楚.
  • 抗血小板药物对干预后脑缺血的影响尚不清楚.

研究的目的:

  • 研究CPG和ASS响应状态对CAS后脑缺血的影响.
  • 在接受CAS的患者中确定CPG和ASS不响应的流行率.

主要方法:

  • 在2010年至2024年间接受选择性CAS和CAS前后MRI的患者的回顾性分析.
  • 根据ASS和CPG反应对患者进行分组.
  • 脑缺血模式的比较,并与药物耐药性或心脏病发作相关.

主要成果:

  • 73. 5% 的患者对 ASS 和 CPG 均有充分的反应.
  • 克洛皮多格勒的不反应 (14. 8%) 比阿司匹林的不反应更频繁 (9. 2%).
  • 在CAS期间的提洛菲班桥梁治疗中,响应状态没有影响介入后的脑梗塞.

结论:

  • 在CAS患者中,抗血小板缺乏反应,尤其是对CPG的反应.
  • 在CAS期间的提罗菲班桥梁减轻了抗血小板不响应对脑梗塞模式的影响.