癌症与FOXP3的关联:X染色体基因分析的系统审查和两种方法
在PubMed上查看摘要
概括
此摘要是机器生成的。福克斯P3基因中的rs3761548 A基因增加了癌症风险,特别是在亚洲和白人群体中. 这种基因变异
科学领域
- 免疫遗传学和癌症生物学
- 瘤微环境与免疫调节
背景情况
- 调节性T细胞抑制抗瘤免疫力.
- 与X结合的FOXP3基因调节Treg功能.
- 对于FOXP3促进体 rs3761548 (C>A) 的癌症作用进行研究.
研究的目的
- 重新评估FOXP3 rs3761548变种与癌症风险之间的关联.
- 采用新的统计方法来解决X染色体复杂性和基于性别的差异.
主要方法
- 在PubMed,谷歌学者和Scopus的系统文献搜索.
- 17个病例对照研究的元分析 (6719名癌症患者,6879名对照患者).
- 统计分析包括X相关的通用线性回归模型 (GLRM) 和性别分层的元分析.
主要成果
- 在白人和亚洲人群中,RS3761548的A基因与癌症风险增加有关.
- 在亚洲人中与乳腺癌相关的特定基因型 (A基因型,AA基因型);在白人中具有抗白血病的AC基因型.
- 在识别关联和考虑风险因素方面,GLRM表现出更强大的稳定性.
结论
- 这项研究引入了一种新的X系基因型数据分析的统计方法.
- FOXP3的作用 (致癌与瘤抑制剂) 取决于背景 (种族,癌症类型,基因型).
- 与rs3761548 C等位基因相关的表观遗传修饰影响FOXP3表达和癌症风险.
相关概念视频
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
In most mammals, females have two X chromosomes (XX) while males have an X and a Y chromosome (XY). The X chromosome contains significantly more genes than the Y chromosome. Therefore, to prevent an excess of X chromosome-linked gene expression in females, one of the two X chromosomes is randomly silenced during early development....
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

