年龄相关的重症监护治疗和结果的性别差异:全国性队列研究
Elsa Hägglöf1, Jesper Eriksson1, Max Bell1
1Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden; Department of Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.
British journal of anaesthesia
|August 29, 2025
概括
虽然男性在重症监护室接受更密集的治疗,但女性的死亡率更高. 年龄显著影响这些性别差异的结果,强调需要在重症监护中进行特定年龄的分析.
科学领域:
- 危急护理医学
- 重症监护室的研究
- 健康上的差异
背景情况:
- 关于ICU治疗和死亡率的性别差异存在不一致的发现.
- 之前的研究表明,年龄可能会调解临床护理结果的性别差异.
研究的目的:
- 为了比较男性和女性ICU患者的患者特征,护理强度和死亡率.
- 调查年龄变化性差异在ICU的结果.
主要方法:
- 使用瑞典重症监护病人的数据 (2012-2024年).
- 使用多变量逻辑回归,包括年龄和性别的相互作用术语,以分析30天死亡率,连续置换疗法和侵入性呼吸.
- 对整个队列和六个诊断小组进行了分析.
主要成果:
- 包括303,875名ICU患者;男性的原始死亡率更高.
- 多变量分析显示女性性别与30天死亡率较高相关 (OR1. 03).
- 男性更有可能接受连续置换疗法和侵入性呼吸;女性在年轻时死亡率较低,年长时死亡率较高.
结论:
- 尽管男性的治疗强度更高,但女性在ICU中的调整死亡率增加.
- 性别之间的年龄特异性死亡风险差异很大.
- 考虑年龄对于对性差异的细微理解至关重要.
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