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在质瘤中,波多普拉宁表达与局部炎症和生存有关

Pegah Mir Seyed Nazari¹, Maximilian J Mair^2,3, Julia Riedl¹

¹Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Scientific reports

|August 29, 2025

概括

在质瘤中,波多普拉宁 (PDPN) 表达与炎症和存活有关. 在IDH1野生型质瘤中,PDPN和PD- L1更为常见,PDPN对这种亚型的生存有负面影响.

科学领域:

神经瘤学
免疫学
癌症生物学

背景情况:

质瘤亚型表现出不同的预后和治疗反应.
瘤微环境,包括炎症,在质瘤的进展中起着至关重要的作用.

研究的目的:

研究质瘤亚型中的波多普拉宁 (PDPN) 表达与患者存活率之间的关联.
探索PDPN表达与质瘤局部和全身炎症标志物的相关性.

主要方法:

在192名质瘤患者中进行前性队列研究.
使用免疫组织化学分析瘤透性淋巴细胞 (TIL),编程细胞死亡配体1 (PD- L1) 和PDPN表达.
进行了统计分析,包括日志等级测试,以评估生存和炎症相关性.

主要成果:

在IDH1野生型 (wt) 中,PDPN和PD- L1表达的频率高于IDH1突变型 (mut) 质瘤.
在IDH1wt质瘤中,PDPN表达与总生存时间显著缩短 (26. 3 vs 12. 5个月).
在具有PDPN和PD- L1表达的IDH1wt质瘤中观察到较高的CD8+和CD68+细胞水平. 在IDH1wt,PDPN阳性,非PD- L1表达性质瘤中发现了高的中性粒细胞与淋巴细胞比率 (NLR).

结论:

结质瘤炎症微环境的组成因IDH1突变状态而异.
波多普拉宁是一种先天性炎症标志物,与IDH1wt质瘤患者的生存预后有显著的关联.
PDPN表达与全身炎症标志物相关,表明其在瘤和宿主免疫之间的相互作用中的作用.

关键词:

质瘤炎症子组其他类型波多普拉宁系统性炎症瘤微环境

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