围产期甲基马暴露会损害小鼠听觉皮层5层神经元的分布和功能
Minzi Chang1,2, Makoto Nakanishi1, Takahiro Nagayama1
1Department of Biosciences, Graduate School of Science and Engineering, Soka University, Hachioji, Tokyo, 192-8577, Japan.
Scientific reports
|August 29, 2025
概括
围产期甲基马 (MMI) 暴露会影响小鼠听觉皮层的发育,影响神经元的分布和功能,不依赖于甲状腺水平. 这表明母亲接触MMI可能会损害后代的听觉认知能力.
科学领域:
- 神经科学
- 发育生物学
- 药理学
背景情况:
- 甲醇 (MMI) 是一种用于治疗甲状腺功能过高的抗甲状腺药物.
- 围产期MMI暴露模型:动物的甲状腺功能低下和听力皮层形.
- 在小鼠中,MMI的甲状腺素水平有所降低,因此对甲状腺素在皮质形中的作用提出了疑问.
研究的目的:
- 研究围产期MMI暴露对血清甲状腺素水平的影响.
- 研究MMI对听觉皮层深层投影神经元的分布和功能的影响.
主要方法:
- 在小鼠中产周MMI暴露.
- 测量血清中的甲状腺素水平.
- 听觉脑干反应的评估.
- 对于Ctip2和神经素的免疫组织化学.
- 树突的形态分析.
- 听力皮层神经元 (CCN和CPN) 的电生理记录.
主要成果:
- MMI暴露导致血清甲状腺素水平和听觉脑干反应的变化很小.
- 在5层中观察到Ctip2阳性皮质结核神经元 (CCN) 的错误分布.
- 不成熟的树突脊柱增加和神经元刺激性发生变化.
- 在深层神经回路活动的总体下降.
结论:
- 围产期MMI暴露会损害小鼠的听觉皮层发育和神经元特性,而不影响显著的甲状腺功能低下.
- 通过甲状腺独立的机制,母亲的MMI暴露对后代的听觉认知构成风险.
相关概念视频
Hair Cells
36.1K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
36.1K
Somatosensation
36.9K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.9K
Sensory Functions of the Skin
9.1K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
9.1K


