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系统性炎症反应指数与手术切除后的原发性皮质脂肪瘤预后的相关性

Weida Chen¹, Wenqing Liu¹, Chengli Miao²

¹Department of Retroperitoneal Tumor Surgery, Peking University International Hospital, No.1 Life Park Road, Life Science Park, Changping District, Beijing, 102206, China.

Scientific reports

|August 29, 2025

概括

系统性炎症响应指数 (SIRI) 是手术后原发性皮质脂肪瘤 (PRPLS) 患者复发的最佳预测指标. 高SIRI水平表明复发的风险显著增加,有助于患者的风险分层.

科学领域:

癌症学
外科瘤学
生物标志物

背景情况:

原发性皮质脂肪瘤 (PRPLS) 是一种罕见的癌症,复发率很高.
有效的预后标记对于手术后的PRPLS患者的治疗至关重要.

研究的目的:

在接受治疗手术的PRPLS患者中评估全身炎症反应指数 (SIRI) 的预后值.
将SIRI的预测性能与其他炎症标志物进行比较.

主要方法:

对经过手术切除的122名PRPLS患者进行了回顾性分析.
通过ROC曲线分析分类为高SIRI和低SIRI组.
使用卡普兰 - 梅尔和考克斯回归的临床数据,实验室参数和生存结果 (RFS,LRFS) 的比较.

主要成果:

SIRI显示出最高的预后准确性 (AUC=0. 831),超过了NLR,PLR和MLR.
高SIRI与较短的无复发存活期 (RFS) 和局部无复发存活期 (LRFS) 相关.
在多变量分析中,SIRI 是唯一独立的RFS预测因子 (HR=5. 19).

结论:

术前SIRI是一种强大且独立的PRPLS复发预后生物标志物.
与传统的炎症标志物相比,SIRI具有更高的复发预测价值.
在PRPLS管理中,SIRI提供了一种简单有效的临床风险分层工具.

关键词:

当地无复发生存率预测生物标志物逆皮肉瘤逆皮瘤这里是SIRI 系统性炎症

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