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Updated: Sep 9, 2025

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
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Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

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在母体免疫激活后表现出认知缺陷的后代中,对精神分裂症风险基因甲基化的发育调节

Rebecca M Woods1,2, Harry G Potter3,4, Hager M Kowash5

  • 1Division of Evolution, Infection and Genomics, School of Biological Sciences, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK. rebecca.woods@manchester.ac.uk.

Molecular psychiatry
|August 29, 2025
PubMed
概括

孕期孕产妇免疫激活会改变胎儿大脑的表观遗传,增加精神分裂症的风险. 这些表观遗传变化在成年时再次出现, 与认知缺陷相吻合, 提供潜在的治疗点.

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Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain13:11

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