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Mu-Heng Li1,2, Yuan Zeng2, Wen Lin3
1School of Pharmaceutical Sciences, Hubei University of Medicine, Shiyan, 442000, China.
Scientific reports
|August 29, 2025
概括
一种新型的二胺 (DPN) 片中的药物,可方便单剂量治疗运动性疾病 (MS). 这种创新剂型可提供即时和延长的药物释放,提高患者的服药性和治疗效果.
科学领域:
- 制药科学
- 药物输送系统
- 配方开发
背景情况:
- 运动性疾病 (MS) 几乎影响着每一个人,在中国通常使用二 (DPN) 来治疗.
- 传统的DPN药片需要频繁服用,长时间使用可能会造成不便,例如在海上航行期间.
研究的目的:
- 开发和评估DPN的新型片内药 (TIT) 配方,以提高移动性疾病的治疗方便性和有效性.
- 创建一个单剂量单位,提供快速和延长的药物释放.
主要方法:
- 预制药研究使用富里埃红外变换 (FTIR) 和差分扫描热量计 (DSC) 来评估药物辅助剂相互作用.
- 通过直接压缩 (DC) 技术,使用微晶纤维素 (MCC) 和聚乙烯氧化物 (PEO) 来制造核心片.
- 一种响应表面方法 (RSM) 分析了MCC和PEO对体外药物释放和胀指数的影响,然后用即时释放进行压涂.
主要成果:
- 增加PEO含量增强了DPN的释放,而MCC则抑制了它.
- 一个优化的核心片 (100 mg PEO,70 mg MCC) 在12小时内释放了90%的药物,胀指数为52%.
- 最终的TIT配方表现出理想的物理化学特性,减少了辅助剂含量和更短的分解时间.
结论:
- 研发的DPN片中的药物 (TIT) 配方成功地提供了单剂型的即时和延长的药物释放.
- 这种新的配方提供了一个有前途的策略, 提高了运动恶心药物治疗的方便性和有效性.
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