无血系干细胞捐赠者的第二次捐献决策经验:描述性的定性研究
Hangting Li1, Lingxi Chen2, Dijiong Wu1
1Hematology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Journal of cancer survivorship : research and practice
|August 29, 2025
概括
第二次全源造血干细胞移植 (allo-HSCT) 是至关重要的,但捐赠者的同意率很低. 了解捐赠者决策可以提高这种救命治疗的同意率.
科学领域:
- 血液学
- 移植免疫学
- 医学伦理
背景情况:
- 第二次全源造血干细胞移植 (allo-HSCT) 是对移植失败或复发的关键治疗方法.
- 全球第二次捐赠的同意率不足限制了治疗的可用性.
- 了解捐赠者决策是提高同意率的关键.
研究的目的:
- 综合了解考虑第二次捐赠的非相关捐赠者的决策经验.
- 确定影响重复造血干细胞捐赠同意的因素.
- 提供旨在增加第二次捐赠同意率的干预信息.
主要方法:
- 根据COREQ的指导方针进行描述性的定性研究.
- 与16名完成第二次捐赠的非相关捐赠者的半结构面试.
- 采访数据的传统内容分析.
主要成果:
- 四个主要主题出现了:最初的反应",锁定"困境,内部动力和外部强化.
- 捐赠者经历了意外,家庭压力和道德困境,
- 积极的第一次捐赠经验和社会支持显著影响了决策.
结论:
- 改善第二次捐赠同意需要有针对性的教育和全面的支持 (个人,家庭,社会).
- 优化首次捐赠体验和培养积极反对于鼓励重复捐赠至关重要.
- 提高捐赠者保留率扩大了疾病复发或移植失败的患者的救生选择.
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