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Updated: Sep 9, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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E3 连接酶 RAD18 针对化 IRF3 终止 IFNB1 转录

Yiting Cai1,2, Jiaqi Zheng1,3, Linlin Zhao1,4

  • 1Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China.

Nature immunology
|August 29, 2025
PubMed
概括

RAD18针对化IRF3进行降解,停止I型干扰素的产生. 这一发现为病毒感染和自身免疫性疾病提供了潜在的治疗点.

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