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在不同放射性亚型的肺腺癌中,EGFR突变状态与临床病理特征,Ki67表达和免疫细胞透之间的相关性

Rirong Qu¹, Yang Zhang², Shenghui Qin³

¹Thoracic Surgery Laboratory, Department of Thoracic Surgery, Tongji HospitalTongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Avenue, Wuhan, 430030, China. qurirong123@163.com.

World journal of surgical oncology

|August 29, 2025

概括

表皮生长因子受体 (EGFR) 突变与肺腺癌 (LUAD) 亚型有关,影响瘤生长和免疫细胞透. 了解这些相关性有助于预测LUAD的进展和预后.

科学领域:

癌症学
放射学
分子生物学

背景情况:

肺腺癌 (LUAD) 呈现不同的放射性亚型.
表皮生长因子受体 (EGFR) 突变状态是LUAD的一个关键因素.
在LUAD亚型中,EGFR突变,临床病理特征和瘤微环境之间的相关性需要阐明.

研究的目的:

在LUD中研究EGFR突变状态与临床病理特征之间的关系.
分析EGFR突变对不同LUAD放射性亚型的Ki67表达和免疫细胞透的影响.
探索放射性特征,如结合与瘤比率 (CTR),如何影响这些相关性.

主要方法:

544名患有病态阶段0- III的LUAD患者进行了切除和EGFR检测.
根据CTR将LUAD分为四组:纯GGO (PGGO),GGO-主导 (GGO-D),SN-主导 (SN-D) 和纯固体结节 (SN).
在CTR组中对临床病理特征,Ki67表达,免疫细胞透和EGFR突变状态进行比较.

主要成果:

在老年人,良好/ 中等差异化,侵入性和较大的瘤中,EGFR突变率较高.
在GGO特征的LUAD (GGO-LUAD) 中,EGFR突变率随着磨砂玻璃不透明度 (GGO) 的降低而增加.
在GGO-LUAD中,Ki67表达与EGFR突变状态相关,在突变瘤中表达更高;SN-LUAD没有显示这种相关性.
与EGFR突变的SN-LUAD相比,EGFR突变的GGO-LUAD对与瘤相关的巨细胞和调节性T细胞的透率较低.

结论:

在LUAD中EGFR突变率与特定的临床病理特征有关.
根据放射性亚型,EGFR突变状态显著影响瘤增殖 (Ki67) 和免疫细胞透.
EGFR突变在GGO-LUAD进展中起作用,这可能解释了这种亚型的更好的预后.

关键词:

相关性皮肤生长因子受体突变地面玻璃的不透明性免疫细胞没有.肺腺癌肺腺癌放射学亚型

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