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在自然衰老的小鼠中通过大脑肠轴改善衰老特性

Chao Feng¹, Yiwen Shou^2,3, Shulin Wu⁴

¹Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.

Chinese medicine

|August 29, 2025

概括

通过调节肠-大脑轴和代谢健康,海多 (SCP) 改善老年小鼠的认知和运动功能. 这项研究阐明了SCP

科学领域:

老年学
营养药物
神经科学
微生物组研究

背景情况:

海聚 (SCP) 是一种传统的营养药,具有多种生物活性特性.
对于SCP的老年保护作用的分子机制尚不清楚.

研究的目的:

研究SCP对老鼠神经运动和认知功能的影响.
阐明潜在的分子机制,包括肠道微生物群和全身代谢变化.

主要方法:

行为测试 (开放场,Y迷宫,巴恩斯迷宫) 评估神经运动和认知能力.
多组学方法 (16S rRNA测序,LC-MS,RNA测序) 分析了肠道微生物群和新陈代谢.
组织学分析 (H&E,免疫组织化学) 检查了大脑和肠道组织.

主要成果:

在老鼠中显著改善学习,记忆和运动功能.
增强了脑部和肝脏的标记, 减少了神经元衰老,
增加有益细菌和减少有害细菌, 以及代谢途径的改变.

结论:

通过肠-大脑轴和代谢平衡的多式调节,SCP具有年龄保护作用.
这些发现支持SCP促进健康长寿的转化潜力.

关键词:

年龄增长大脑-肠轴代谢学自然老化的小鼠海洋黄瓜多

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