便白细胞雌激酶水平预测内学严重性作为炎症性肠病的替代生物标志物
Feng-Pai Tsai1,2, Meng-Tzu Weng1,3, Hsin-Yun Wu1,4
1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Clinical chemistry and laboratory medicine
|August 30, 2025
概括
便白细胞化酶 (FLE) 在预测炎症性肠病 (IBD) 严重性方面表现有前途,与便calprotectin相关性良好. 这种非侵入性标志物有助于评估性结肠炎和克罗恩病的内活性.
科学领域:
- 胃肠病学和肝病学
- 临床诊断
- 生物标志物研究
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎和克罗恩病,需要精确监测疾病活动.
- 便中的calprotectin是IBD的广泛使用的生物标志物,但其成本和可用性可能受到限制.
- 便白细胞化酶 (FLE) 已成为一种潜在的替代或补充的非侵入性标记物.
研究的目的:
- 评估便白细胞化酶 (FLE) 的预测价值,以评估炎症性肠病 (IBD) 的内学严重程度.
- 在性结肠炎和克罗恩病患者中比较FLE与便calprotectin和C-反应蛋白 (CRP) 的诊断性能.
- 在IBD队列中确认FLE和便calprotectin水平之间的相关性.
主要方法:
- 一组203名IBD患者 (100名性结肠炎,103名克罗恩病) 接受了前性结肠镜检查.
- 在内镜检查后一个月内采集了便样本,以分析便白细胞酶 (FLE) 和便calprotectin.
- 用接收器操作特征 (ROC) 曲线评估诊断准确性,计算FLE,便calprotectin和CRP曲线下的面积,以预测内镜分数.
主要成果:
- 在疹性结肠炎 (r=0. 432, p< 0. 001) 和克罗恩病 (r=0. 311, p=0. 001) 两种疾病中,白细胞酶 (FLE) 水平与便中calprotectin显著相关 (r=0. 425, p< 0. 001).
- 对于性结肠炎,预测显著炎症的AUC (梅奥分数≥2) 为FLE的0. 731,便calprotectin的0. 785,CRP的0. 558.
- 对于克罗恩病,预测显著炎症的AUC (简单内镜评分≥7) 是FLE的0. 706,便calprotectin的0. 800,CRP的0. 770. 在FLE和便calprotectin性能之间没有发现显著差异.
结论:
- 便白细胞化酶 (FLE) 是一种可靠的生物标志物,在炎症性肠病 (IBD) 中与便calprotectin相关.
- 在性结肠炎和克罗恩病中,性结肠炎具有显著的预测价值.
- FLE作为一种有价值的非侵入性工具来监测IBD活动,其性能与便calprotectin相美.
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