实施结核病预防治疗:印度大规模举措的教训
M Das1, A Kalra1, A S ThekkePurakkal1
1FIND, New Delhi, India.
概括
在家庭接触者中,3个月的利法丁- 异胺 (3HP) 治疗方案显示结核病预防治疗 (TPT) 的完成率很高. 与标准的6个月异化治疗方案相比,这种较短的TPT选择显示了可管理的不良事件和优异的坚持.
科学领域:
- 公共卫生
- 传染性疾病
- 临床试验
背景情况:
- 结核病 (TB) 仍然是一个重大的全球健康挑战.
- 世界卫生组织越来越多地建议使用较短时间的结核病预防治疗方案.
- 印度结核消灭联合计划 (JEET) 正在评估新的结核治疗策略.
研究的目的:
- 评估3个月的利法丁-异胺 (3HP) 治疗方案的早期实施结果.
- 将3HP的特征,不良事件和治疗结果与标准6个月的每日异化物 (6H) 治疗方案进行比较.
- 评估3HP在印度现实环境中的可行性和有效性.
主要方法:
- 对肺结核患者的家庭接触者进行了一项描述性队列研究.
- 在选定的地区, HHC 获得了 3HP 或 6H TPT.
- 在两组中收集和比较了HHC特征,不良事件和TPT完成的数据.
主要成果:
- 总共有635个HHC在3HP上启动,24350个HHC获得了6H.
- 大约10%的3HP的HHC经历了AE,而6H则为4%.
- 与6H (84%,P < 0. 001) 相比,3HP的完成率显著更高.
结论:
- 3HP疗法实现了高TPT完成率,可控不良事件的发生率较低.
- 这些发现支持在国家结核病计划中扩大3HP治疗方案.
- 对于高结核病负担的国家来说,3HP是一个有前途且有效的较短的TPT选项.
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