长期COVID患者的季节性冠状病毒诱导免疫印记和之前的疹病毒感染
在PubMed上查看摘要
概括
此摘要是机器生成的。长期COVID患者表现出免疫反应的改变,包括SARS-CoV-2抗体的减少和季节性冠状病毒抗体的增加,这表明免疫印记. 抗体类别的变化和较低的细胞大脑病毒抗体可能导致长期COVID症状.
科学领域
- 免疫学
- 病毒学
- 传染性疾病
背景情况
- 长期COVID (LC) 影响了5%-10%的SARS-CoV-2感染者.
- 了解LC的免疫基础对于开发有效的治疗方法至关重要.
- 之前的感染可能会影响对SARS-CoV-2的免疫反应.
研究的目的
- 在长期COVID中调查SARS-CoV-2幽默免疫力.
- 评估特有冠状病毒免疫印记的作用.
- 评估之前的疹病毒感染对长期COVID的影响.
主要方法
- 在47名LC患者和41名对照人群中,对抗SARS-CoV-2,季节性冠状病毒和疹病毒的抗体水平进行比较.
- 使用ELISA和微块阵列面板进行抗体评估.
- 进行PCR检测病毒RNA/DNA,并评估抗核自身抗体.
主要成果
- 慢性肺炎患者的IgG/IgA降低,但冠状病毒 (OC43,HKU1) 的IgG增加.
- 相对于IgG,SARS-CoV-2抗峰IgM的升高表明抗体类别的变化受损.
- 在LC患者中,较低的细胞巨病毒 (CMV) p65IgG水平与疲劳严重程度有负相关性.
结论
- 季节性冠状病毒的免疫印记可能有助于长期COVID中SARS-CoV-2的免疫逃逸.
- 抗体类别的改变可能会促进长期COVID病毒的持续性.
- 降低的CMV IgG水平与长期COVID患者的疲劳严重程度相反相关.
相关概念视频
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Overview
Vaccination is the administration of antigenic material from pathogens to confer immunity against a specific microorganism. Vaccination primes the immune system to recognize and mount an immune response faster and more effectively if the real pathogen is encountered. Vaccinations are one of the most efficient ways to protect both individual humans and the general public from disease. A growing anti-vaccination skepticism risks the successes of vaccination programs that helped reduce...
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

