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Updated: Sep 9, 2025

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
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通过DRAM1稳定VAMP8,使自细胞和溶酶体融合,并促进转移性扩散

Rui Zhang1, Vincenzo Torraca2, Chaojun Yan1

  • 1National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China.

Autophagy
|August 30, 2025
PubMed
概括

调节DNA损伤的自调节器1 (DRAM1) 稳定了VAMP8在溶酶体上,增强了自细胞与溶酶体的融合. 这一过程促进肝细胞癌 (HCC) 转移,表明DRAM1是治疗点.

关键词:
自细胞与溶酶细胞的融合一个DRAM1一个STUB在VAMP8中在外流无处不在

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