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优化皮里米丁治疗:DPYD基因型剂量对严重毒性率的现实影响

Anouk H E van Kan1, Ankie M Harmsze1, Karin Herbschleb2

  • 1Department of Clinical Pharmacy, St. Antonius Hospital, Utrecht/Nieuwegein, The Netherlands.

British journal of clinical pharmacology
|August 30, 2025
PubMed
概括

在DPYD基因型导向的甲剂量测试中,在携带变体和野生型患者中显示出类似的严重毒性率. 个人剂量定位至关重要,特别是对于C.1236G>A载体,以优化安全性.

关键词:
DPD 的缺陷一个DPYD皮里米丁基因定型药物遗传学

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