全球和区域mpox死亡率统计:全面的系统审查和元分析
Srivatsa Surya Vasudevan1, Tiba Yamin Kandrikar2, Prachi Cooner3
1Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Pathogens and global health
|August 30, 2025
概括
全球Mpox病毒 (MPXV) 死亡率有所下降,尤其是在COVID后和流行地区. 然而,艾滋病毒感染者面临极高的mpox死亡风险,需要有针对性的干预措施.
科学领域:
- 流行病学
- 传染性疾病
- 公共卫生
背景情况:
- 在全球范围内,Mpox病毒 (MPXV) 死亡趋势尚不清楚.
- 对于公共卫生干预和资源分配来说, 了解mopox死亡率至关重要.
研究的目的:
- 系统地评估全球和地区的mpox死亡率.
- 分析不同地理位置和时间段的mopox死亡率分层.
- 确定影响mopox死亡率的因素,包括HIV同时感染.
主要方法:
- 一个全面的系统审查和研究报告mopox死亡率的元分析.
- 在PubMed,Embase,Scopus和Web of Science数据库中搜索到2025年6月.
- 使用随机效应的比例元分析,灵敏度分析和元回归.
主要成果:
- 总的全球mopox死亡率为3.1%,随着时间的推移观察到显著下降 (2016年前11.4%至COVID后1.5%).
- 艾滋病毒同时感染的个体的死亡率显著增加 (83. 8%) 并且因地区而异 (非洲最高6. 3%,欧洲最低0. 1%).
- 出版年份是降低死亡率的重要预测因素,表明结果有所改善.
结论:
- 全球mopox死亡率随着时间的推移而下降,在COVID后的时代进一步下降.
- 同时感染艾滋病毒的个体是高风险群体,需要紧急,有针对性的干预措施.
- 疫情死亡率的地域差异依然存在,这凸显了对特定区域的公共卫生战略的需要.
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