在疑似非酒精性脂肪肝患者中,阻塞性睡眠呼吸暂停和肝纤维化之间的关联
在PubMed上查看摘要
概括
此摘要是机器生成的。在疑似非酒精性脂肪性肝病 (NAFLD) 的患者中,阻塞性睡眠呼吸暂停 (OSA) 与晚期肝纤维化有关. 在经过活检验证的队列中,使用黄金标准的诊断工具证实了这一发现.
科学领域
- 肝病学
- 睡眠医学
- 内部医学
背景情况
- 阻塞性睡眠呼吸暂停 (OSA) 和非酒精性脂肪肝 (NAFLD) 是普遍存在的疾病.
- 之前研究OSA与肝纤维化之间的关联经常使用非侵入性工具或专注于特定的患者群体.
- 在活检证明的NAFLD患者中,OSA与肝纤维化之间的关系需要进一步研究.
研究的目的
- 确定阻塞性睡眠呼吸暂停 (OSA) 是否与疑似非酒精性脂肪性肝病 (NAFLD) 患者的肝脏纤维化有关.
- 用黄金标准的诊断方法对这两种情况进行调查.
主要方法
- 预计包括97名因怀疑NAFLD而接受皮肤透过肝脏活检的患者.
- 在实验室进行多睡眠检查,以诊断中度至重度的OSA (呼吸暂停- 呼吸暂停指数≥15次/小时).
- 使用NASH-CRN评分系统确定肝纤维化的阶段,F≥3定义为晚期纤维化.
主要成果
- 40名患者有晚期纤维化,63名患者有中度至重度的OSA.
- 与F0- 2纤维化患者相比,晚期纤维化患者的中度至重度OSA患病率显著高 (82%;p<. 0037).
- 在对共变量进行调整后,中度至重度的OSA仍与晚期纤维化相关 (OR 3. 48; p=. 045). 夜间缺氧标志物也显示出相关性,但OSA与肉脂症或NASH无关.
结论
- 在经过活检证明的多中心NAFLD患者中证实了阻塞性睡眠呼吸暂停 (OSA) 和肝纤维化之间的独立关联.
- 这项研究使用了OSA和NAFLD的黄金标准诊断工具,加强了研究结果.
- 这些结果强调了在治疗肝纤维化的NAFLD患者时考虑OSA的重要性.
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