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相关概念视频

Channel Rhodopsins01:11

Channel Rhodopsins

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Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
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Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Photochemical Electrocyclic Reactions: Stereochemistry01:26

Photochemical Electrocyclic Reactions: Stereochemistry

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The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
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Color Vision01:24

Color Vision

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Color perception begins in the retina, the light-sensitive layer at the back of the eye. Two main theories explain how colors are seen: the trichromatic theory and the opponent-process theory. The trichromatic theory, proposed by Thomas Young in 1802 and extended by Hermann von Helmholtz in 1852, suggests that color vision is based on three types of cone receptors in the retina. These cones are sensitive to different but overlapping ranges of wavelengths corresponding to red, blue, and green.
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Anatomy of the Eyeball01:20

Anatomy of the Eyeball

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The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
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Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

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Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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相关实验视频

Updated: Sep 9, 2025

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
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Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

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染色体变异

Franck Pellestor1,2, Jean Baptiste Gaillard3, Benjamin Ganne3,4

  • 1Unit of Chromosomal Genetics and Research Platform Chromostem, Department of Molecular Genetics and Cytogenomics, Site Unique de Biologie (SUB), Montpellier CHU, Montpellier Cedex 5, France. f-pellestor@chu-montpellier.fr.

Methods in molecular biology (Clifton, N.J.)
|August 30, 2025
PubMed
概括
此摘要是机器生成的。

染色体复杂的重组导致癌症中的基因融合和破坏. 这种巨大的基因组事件在癌症发生初期, 推动了瘤的进化和进展.

关键词:
染色体生成染色体变异删除基因融合前列腺癌间歇性演变转移情况一个瘤

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High-Accuracy Correction of 3D Chromatic Shifts in the Age of Super-Resolution Biological Imaging Using Chromagnon
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Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
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相关实验视频

Last Updated: Sep 9, 2025

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
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High-Accuracy Correction of 3D Chromatic Shifts in the Age of Super-Resolution Biological Imaging Using Chromagnon
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High-Accuracy Correction of 3D Chromatic Shifts in the Age of Super-Resolution Biological Imaging Using Chromagnon

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Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
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科学领域:

  • 基因组学
  • 癌症生物学
  • 分子瘤学

背景情况:

  • 染色体是复杂的基因组重组,涉及多个染色体.
  • 它导致基因融合和破坏, 在包括前列腺癌在内的各种癌症中观察到.
  • 染色体形成的确切机制在很大程度上是未知的.

研究的目的:

  • 阐明染色体形成的基础机制.
  • 了解染色体在瘤发生和瘤进展中的作用.
  • 调查与染色体相关的基因组配置.

主要方法:

  • 对癌症基因组复杂染色体重组的分析.
  • 在特定的基因组环境中识别双链断裂模式.
  • 染色体间和染色体内转位和删除的特征.

主要成果:

  • 染色体复杂性涉及广泛的染色体重新排列,没有显著的副本数量改变.
  • 这些重排与特定的基因组配置有关,比如开放的染色体和活跃的转录.
  • 染色体可能在癌症发育的早期发生,并导致克隆进化.

结论:

  • 染色体是癌症基因组不稳定的重要驱动因素.
  • 它支持突破性瘤进化模型的快速基因组变化.
  • 需要进一步的研究,以充分理解和潜在的向色谱机制.