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基于MRI的模型,用于在患有胆囊癌的患者中预先预测三级淋巴体结构

Ying Xu ¹, Zhuo Li ², Weihua Zhi ¹

¹Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
²Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
³State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁴Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁵Beijing Key Laboratory of Cell and Gene Therapy for Digestive System Tumor, Beijing, China.
⁶Key Laboratory of Gene Editing Screening and Research and Development (R&D) of Digestive System Tumor Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁷Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.
⁸Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.
⁹University of Electronic Science and Technology of China, Chengdu, China.
¹⁰Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹¹Magnetic Resonance Imaging Research, General Electric Healthcare, Beijing, China.
¹²Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. yingjm@cicams.ac.cn.
¹³State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. yingjm@cicams.ac.cn.
¹⁴Beijing Key Laboratory of Cell and Gene Therapy for Digestive System Tumor, Beijing, China. yingjm@cicams.ac.cn.
¹⁵Key Laboratory of Gene Editing Screening and Research and Development (R&D) of Digestive System Tumor Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. yingjm@cicams.ac.cn.
¹⁶Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China. zhoujx888@126.com.
¹⁷Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. zhaoxinming@cicams.ac.cn.
¹⁸Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. yefeng@cicams.ac.cn.

⁰Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Insights Into Imaging +

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2025年八月30日

在PubMed上查看摘要

概括

这项研究开发了一种基于磁共振成像 (MRI) 的放射学模型,用于预测胆囊癌 (GBC) 的三级淋巴细胞结构 (TLS). 综合模型准确预测患者的预后,分层化手术后的无复发存活率和免疫治疗后的整体存活率.

科学领域

癌症学
放射学
免疫学

背景情况

三级淋巴体结构 (TLS) 在癌症免疫和预后方面至关重要.
在手术前预测TLS状态可以指导胆囊癌 (GBC) 的治疗策略.

研究的目的

开发和验证基于手术前磁共振成像 (MRI) 的放射学模型,用于预测GBC中的内TLS.
评估该模型对患者预后分层的能力,包括无复发生存率 (RFS) 和整体生存率 (OS).

主要方法

从手术前GBC患者的MRI扫描中提取了放射性特征.
在独立的队列中开发和验证了一种联合的临床放射学模型.
使用后勤回归和ROC分析来评估模型性能并确定预测因素.

主要成果

综合模型在预测TLS状态方面表现出很高的准确性 (在训练队列中AUC为0. 891).
在GBC患者中,术前TLS状态独立预测RFS.
该模型有效地分类了手术后的RFS和免疫治疗后的OS.

结论

基于MRI的组合放射学模型可以在手术前可靠地预测GBC中的内TLS状态.
该模型是预测GBC患者的预后和指导治疗决策的宝贵工具.

关键词:

胆囊癌磁共振成像辐射学三级淋巴体结构