60-64岁男性心血管查结果:DANCAVAS II试验
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在PubMed上查看摘要
概括
此摘要是机器生成的。对老年男性进行心血管疾病查并没有降低死亡率,但增加了严重出血事件. 需要进一步的后续行动来评估基于人口的查策略的长期结果.
科学领域
- 心脏病学
- 预防医学
- 公共卫生
背景情况
- 基于人群的心血管疾病 (CVD) 查对死亡率的益处的证据有限.
- 查亚临床心血管疾病可能有助于降低死亡率.
研究的目的
- 对60至64岁男性全因死亡率进行临床下心血管疾病 (CVD) 综合查的有效性进行评估.
- 评估查对重大心血管不良事件 (MACE) 和严重出血的影响.
主要方法
- 进行了一项并行随机对照试验,涉及60至64岁的丹麦男性.
- 参与者被随机分配到1:4的CVD查邀请或对照组.
- 查包括冠状动脉化,动脉瘤,心房动,外周动脉疾病,高血压,糖尿病和高胆固醇,以及包括他类药物,阿司匹林和监测在内的干预措施.
主要成果
- 在7年的中位随访后,干预组 (9. 3%) 和对照组 (9. 9%) 之间没有显著的死亡率差异 (HR=0. 94; p=0. 169).
- 主要心血管不良事件 (MACE) 也没有显著差异 (10. 2%与10. 6%;HR=0. 96;p=0. 319).
- 在查邀请组中严重出血事件显著增加 (6. 0% vs 5. 1%;HR=1. 18;p=0. 007),包括胃肠道出血.
结论
- 在60至64岁的男性中,基于CT的综合性查并没有降低7年死亡率.
- 查策略导致严重出血事件的增加.
- 由于该试验为10年事件评估提供了动力,因此需要进一步的后续调查.
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