复发性急性淋巴细胞白血病儿童的复发过程中的传染性并发症:描述性分析
1Division of Hematology/Oncology/Bone Marrow Transplant, Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Pediatric hematology and oncology
|August 30, 2025
概括
在复发性急性淋巴细胞白血病 (ALL) 的再诱导化疗期间,感染很常见,导致更长的住院时间. 这种高危儿科患者需要更安全的治疗策略.
科学领域:
- 儿童瘤学
- 传染性疾病
- 血液学
背景情况:
- 在儿童中复发的急性淋巴细胞白血病 (ALL) 具有重大挑战,包括感染风险增加和与治疗相关的死亡率.
- 强化化疗是复发ALL的标准,但严重的感染可能会阻碍治愈治疗.
研究的目的:
- 在儿科 ALL复发患者中确定化疗再诱导期间感染的发生率和模式.
- 确定与感染相关的因素及其对住院和生存的影响.
主要方法:
- 综合化疗再诱导治疗的43名儿科ALL复发患者的回顾性病理表.
- 收集患者人口统计,治疗,中性质衰竭持续时间,感染发生率,住院时间和整体存活率的数据.
主要成果:
- 51% 的患者至少有一次感染; 16% 患有真菌感染.
- 感染与显著更长的住院时间有关 (中位数为17天而不是7天).
- 过高血糖和长时间的中性质减退 (≥21天) 显示出感染风险增加的趋势,但不具有统计学意义. 整体存活率不受感染状态的影响.
结论:
- 在ALL再诱导化疗期间,感染性并发症很常见,因此需要改善支持性治疗.
- 开发更安全,更有针对性的再诱导策略至关重要, 以优化 ALL 复发儿童的治疗结果.
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