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菜叶提取物通过抗炎,抗氧化和抗菌作用促进伤口愈合

Priscila de Lima Paula¹, Mariana Hauck Vianna¹, Júlia Bertolini Fajardo¹

¹Laboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.

Chemistry & biodiversity

|August 30, 2025

概括

来自Plinia cauliflora叶 (EEPC) 的乙醇提取物具有显著的抗氧化,抗炎和抗菌特性. 这种天然化合物还促进纤维细胞迁移,表明具有强大的伤口愈合应用潜力.

科学领域:

植物化学
药理学
生物医学

背景情况:

传统上用于治疗伤口和炎症.
巴西的生物多样性提供了新型治疗化合物的潜力.

研究的目的:

研究P.cauliflora叶子 (EEPC) 乙醇提取物的植物化学成分.
评估EEPC的生物活性,包括抗氧化,抗炎,抗微生物和伤口愈合的潜力.

主要方法:

使用UHPLC-MS的植物化学分析确定了13种化合物,其中酸是最丰富的.
通过DPPH测定评估抗氧化活性,测量活性氧物种 (ROS) 和脂质过氧化抑制.
通过测量IL-1β和TNF-α水平来评估抗炎作用.
使用最小抑制度 (MIC) 确定对Pseudomonas aeruginosa和Candida albicans的抗菌活性.
评估了黄金葡萄球菌生物膜抑制和纤维细胞迁移的伤口愈合潜力.

主要成果:

EEPC 显示出显著的抗氧化活性 (IC50 = 4. 42 μg/ mL),减少了 63% 的 ROS 和 63. 69% 的脂质过氧化.
显示抗炎作用,降低IL-1β的40%和TNF-α的74%.
对P. aeruginosa和C. albicans表现出抗菌活性 (MIC=250μg/mL) 并降低了S. aureus生物膜粘附率95. 40%.
增强纤维细胞迁移95. 40%,表明伤口愈合能力.

结论:

它具有显著的抗氧化,抗炎和抗菌特性.
由于纤维细胞迁移的增强, 提取物对伤口愈合有希望.
这些发现强调了P.cauliflora和巴西生物多样性的治疗潜力.

关键词:

草植物药用植物类化合物皮肤上的伤口伤口愈合

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