母婴Tdap与婴儿肺炎球菌疫苗接种之间的相互作用
Eline Van den Bosch1, Helene Vermeulen2, Esra Ekinci1
1Centre for the Evaluation of Vaccination, University of Antwerp, Wilrijk, Belgium.
The Journal of infectious diseases
|August 30, 2025
概括
孕妇在怀孕期间接种疹,白血病和非细胞性咳 (Tdap) 疫苗,与婴儿中肺炎球菌疫苗相关的血清型携带率较高有关. 需要进一步研究以了解这一发现的临床意义.
科学领域:
- 免疫学
- 疫苗学
- 儿童传染病
背景情况:
- 在怀孕期间接种疹,白血病和非细胞性咳 (Tdap) 疫苗可能会影响婴儿对肺炎球菌联合疫苗 (PCV) 的免疫反应.
- 母婴Tdap疫苗对婴儿鼻携带肺炎球菌疫苗血清型的影响尚不清楚.
研究的目的:
- 研究孕妇在怀孕期间接种Tdap疫苗与婴儿肺炎球菌疫苗相关血清型携带之间的关联.
- 分析不同肺炎球菌结合疫苗方案对血清型携带的影响.
主要方法:
- 在比利时 (2018-2022) 采集了3,298个6至30个月龄的婴儿的鼻抽样.
- 使用培养基 (Quellung反应) 和分子方法 (qPCR) 评估Streptococcus pneumoniae携带和血清定型.
- 用于评估母体Tdap疫苗接种与婴儿肺炎球菌血清型携带之间的关联的物流通用估计方程模型.
主要成果:
- 在怀孕期间接种Tdap疫苗的母亲所生婴儿的PCV13相关血清型携带显著增加.
- 接受PCV10或PCV10/PCV13混合方案的婴儿与仅接受PCV13的婴儿相比,PCV13相关的血清型携带增加.
- 在接种Tdap疫苗的母亲的婴儿中观察到6C血清型携带的显著增加;在非疫苗血清型携带中没有发现差异.
结论:
- 孕妇在怀孕期间接种Tdap疫苗与婴儿肺炎球菌疫苗相关的血清型携带增加有关.
- 这种增加的携带的临床影响需要进一步研究.
- 未来的研究应将疫苗血型携带与抗体水平相关联,以指导母婴疫苗接种策略.
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