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Updated: Sep 9, 2025

Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
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联合不可逆转的四环素破坏酶抑制剂

Ruihao Li1, Yao-Peng Xue2, Steven T Le1

  • 1Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130-4899, United States.

ACS infectious diseases
|August 30, 2025
PubMed
概括

研究人员开发了针对四环素破坏酶 (TDases) 的新型共价抑制剂,这些酶导致抗生素耐药性. 这些抑制剂成功地恢复了耐药细菌的四环素活性,为抗酶失活提供了有前途的策略.

关键词:
抗生素耐药性任何甲同价酶抑制黄素单氧化酶四环素的使用四环素破坏酶

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