相关实验视频

Updated: May 10, 2026

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process

Published on: March 21, 2014

长期的抗真菌药物输送假牙材料与血启动的表面功能化

Jianchuan Wen¹, Parveez A Abdul-Azees², E Matthew Lamb³

¹Chemistry Department, University of Massachusetts Lowell, One University Ave, Lowell, MA 01854-2874, USA.

Colloids and surfaces. B, Biointerfaces

|August 30, 2025

概括

这项研究通过将聚甲酸 (PMAA) 与聚甲基甲酸 (PMMA) 结合,开发了一种新的假牙材料. 修改后的材料有效地结合抗真菌药物,防止Candida相关的假牙炎 (CADS) 至少30天.

科学领域:

生物材料科学
菌群学
表面化学

背景情况:

基于聚甲基甲酸盐 (PMMA) 的假牙容易感染Candida,导致Candida相关的假牙牙炎 (CADS).
目前对CADS的治疗可能受到重复感染和物质易感性的限制.
需要更好的假牙材料来有效预防真菌感染.

研究的目的:

开发一种新的假牙树脂表面功能化方法.
通过聚 (甲酸) (PMAA) 的共价键增强假牙材料的抗真菌性能.
评估改性材料的药物结合能力,抗候性疗效,耐用性和生物相容性.

主要方法:

用两步的血启动表面功能化方法将PMAA移植到假牙树脂上.
分析了不同反应条件对PMAA移植产量和材料性能的影响.
使用含有药物的PMAA移植材料对Candida菌株SC5314和UME6进行了抗候群活性测试.
用于对疗效和生物相容性进行评估,采用了殖民地形成单位计数,光显微镜和XTT测定.

主要成果:

PMAA移植显著提高了假牙材料与抗真菌药物miconazole的结合能力.
经过修改后的材料表现出持续的抗候菌作用,根除了一种Candida菌株,并抑制另一种菌株长达30天.
通过XTT测试证实,PMAA移植材料具有很高的生物相容性.
功能化过程提高了对真菌再注射的抵抗力.

结论:

用PMAA启动表面功能化为创建先进假牙材料提供了一个有前途的策略.
这些改造材料显示出预防和治疗菌相关的假牙炎 (CADS) 的巨大潜力.
开发的材料提供了耐用的,生物相容的,有效的替代方法来减少假牙使用者的真菌感染.

关键词:

生物相容性黄虫假牙提供药物科植物血聚乙烯 (甲基酸)

更多相关视频

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

Published on: December 26, 2016

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Published on: March 28, 2025

相关概念视频

Bacterial Signaling

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...

Biofilms

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...

The Oral Microbiota

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...