含有化衍生物的电聚3-酸纤维:用于抗癌的结构,光物理和光动力学特性
Polina M Tyubaeva1, Ivetta A Varyan1, Arslan B Mazitov2
1Department of Biological and Chemical Physics of Polymers, Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygina ul. 4, Moscow 119334, Russian Federation; Academic Department of Technology and Chemistry of Innovative Materials, Plekhanov University of Economics, Stremyanny per. 36, Moscow 117997, Russian Federation.
Colloids and surfaces. B, Biointerfaces
|August 30, 2025
概括
新型电聚3-酸 (PHB) 系统有效地提供酸衍生物 (PheoD) 光敏剂,用于增强抗癌光动力疗法 (PDT). 这些PHB-PheoD系统显示出改善的抗菌活性和受控释放,提高PDT的效率.
科学领域:
- 生物材料科学
- 聚合物化学
- 光动力疗法
背景情况:
- 光动力疗法 (PDT) 需要有效的光敏剂输送系统.
- 聚3-酸 (PHB) 是一种可生物降解的聚合物,具有生物医学应用的潜力.
- 化衍生物 (PheoD) 是PDT的有希望的光敏感剂.
研究的目的:
- 开发和描述用于PheoD输送的新型电PHB系统.
- 评估PheoD在抗癌PDT中对PHB特性和性能的影响.
- 评估PHB-PheoD系统的光物理,形态,机械,释放,细胞毒性和抗菌特性.
主要方法:
- PHB和PheoD的电旋结合.
- 扫描电子显微镜 (SEM) 和原子力显微镜 (AFM) 用于形态学.
- 超分子结构的X射线衍射 (XRD) 和电子磁共振 (EPR).
- 对机械行为进行拉伸测试.
- 在体外释放研究和A431细胞的细胞毒性测定.
- 对阳性和阴性细菌进行抗菌活性测试.
主要成果:
- 加入PheoD改变了PHB表面形态,并显著增加了拉力强度.
- 最佳的PheoD负载 (0. 03%) 导致释放受调节,毒性降低,抗菌效率提高.
- PHB-mC2NH2 呈现高累积释放率 (35%),强烈的抗菌活性和高光诱导毒性.
- PHB-mC2N+的释放延迟 (30%),抗菌活性略低,光诱导毒性较低.
- 与纯PheoD相比,PHB-PheoD系统的PDT效率分别高出80%和40%.
结论:
- 电PHB-PheoD系统为抗癌PDT提供了一个有前途的平台.
- 开发的系统提供了可控释放,增强了抗菌性质,并提高了PDT的疗效.
- 这些基于PHB的材料代表了针对癌症治疗策略的重大进展.
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