纳米颗粒对人类微生物群的长期毒性影响
Shiva Sanati1, Azam Bakhti2, Fatemeh Mohammadipanah1
1Pharmaceutical Biotechnology Lab, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science, University of Tehran, Tehran 14155-6455, Iran.
概括
通过影响细胞和肠道微生物群,合成纳米材料对人类健康构成风险. 修改纳米材料的特性和利用有益的微生物可以减轻这些不良影响.
科学领域:
- 环境科学
- 毒理学
- 微生物学
背景情况:
- 合成纳米材料越来越多地用于各种行业,包括医药,食品,化品和农业.
- 这些物质可以通过多种途径 (皮肤,肺,胃肠道) 进入人体并进入全身循环.
- 在肠道中的积累是一个重大问题,可能导致肠道失调.
研究的目的:
- 调查合成纳米材料对人类细胞和肠道微生物的有害影响.
- 探索减轻纳米材料毒性的策略.
- 讨论纳米材料在食品,水和药物中的应用.
主要方法:
- 对纳米材料与生物系统相互作用的现有研究进行文献审查和综合.
- 对人类细胞和微生物群落的直接和间接影响的分析.
- 评估潜在的缓解策略,包括物理化学修改和微生物干预.
主要成果:
- 纳米材料可以改变人体细胞并破坏肠道微生物平衡 (失调).
- 纳米材料的物理化学修饰可以部分减少不良影响.
- 某些肠道微生物在减轻纳米材料毒性方面具有潜力,提供益生菌/后生物途径.
- 纳米材料可以影响微生物群落内的水平基因转移率.
结论:
- 纳米材料的广泛使用需要根据剂量,持续时间,类型和毒性进行仔细的风险评估.
- 了解纳米材料,人体细胞和肠道微生物组之间的复杂相互作用对于安全应用至关重要.
- 需要进一步研究基于微生物的解毒策略.
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