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Updated: Sep 9, 2025

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
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Published on: January 29, 2018

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通过MAT2A-AdoMetDC轴上调聚胺合成的SUMO E1共价基抑制剂

Shuai Zhang1, Jinzhu Li1, Zhiying Wang1

  • 1Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), Wuhan 430068, China; Hubei Key Laboratory of Industrial Microbiology, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068, China.

Bioorganic chemistry
|August 30, 2025
PubMed
概括

我们发现了新型的SUMO E1共价抑制剂 (CAI),这些抑制剂会破坏蛋白质SUMOylation,并意外地促进聚胺合成. 结合这些CAI与多胺抑制剂,对癌细胞产生协同作用.

关键词:
同价抑制剂甲氨基基转移酶多氨酸鱼鱼小型泛素类修饰剂

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