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Updated: Sep 9, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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抑制ACE的三LL-X的结构-活性关系和分子相互作用机制

Cuicui Yang1, Mengmeng Cai1, Zhengkun Ma1

  • 1Guangxi Key Laboratory for Polysaccharide Materials and Modifications, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.

Bioorganic chemistry
|August 30, 2025
PubMed
概括

这种C端氨基酸显著影响血管转化酶 (ACE) 抑制性活性. 在Leu-Leu-Tyr中用氨酸或氨酸取代氨酸降低了ACE抑制,突显了氨酸在抗高血压设计中的关键作用.

关键词:
抗素转化酶抑制分子对接光谱分析结构与活动的关系

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