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在意大利西北部的一个队列中,出生体重与成年死亡率之间的关联
Lorenzo Milani1, Elena Farina2, Paola Armaroli3
1Centre for Biostatistics, Epidemiology, and Public Health, Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy.
Public health
|August 30, 2025
概括
低出生体重增加了成年人死于所有原因和心血管疾病的风险. 这种风险取决于性别,影响女性的心血管死亡率和男性的神经系统疾病.
科学领域:
- 公共卫生
- 流行病学
- 纵向研究
背景情况:
- 全球约有15%的新生儿体重不足,
- 低出生体重与死因增加有关, 其中包括心血管疾病.
- 高出生体重也与某些疾病的风险增加有关,
研究的目的:
- 研究出生体重与成年人因各种原因的死亡率之间的联系.
- 用图林纵向研究 (TLS) 的数据进行综合分析.
主要方法:
- 来自都灵纵向研究 (TLS) 的健康管理队列的分析.
- 包括20世纪20年代出生的2992人,从1971年到2013年进行跟踪.
- 使用生存和竞争性风险模型评估出生体重 (<2500g,<2800g,≥4000g) 和所有原因,心血管,癌症,呼吸道,神经系统和消化系统疾病的死亡率.
主要成果:
- 低出生体重 (<2500g或<2800g) 成为所有原因死亡的重要风险因素.
- 低出生体重与心血管疾病死亡风险增加有关.
- 性别分层分析显示,低出生体重与女性心血管死亡率和男性神经系统疾病死亡率有关.
结论:
- 低出生体重是成年人死亡的关键风险因素,包括所有原因和特定疾病,如心血管和神经系统疾病.
- 这些发现强调了解决非正常出生体重以减轻长期健康后果的重要性.
- 这项研究强调需要采取旨在减少低出生体重的公共卫生政策.
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