全球COPD-OSA重叠综合征的流行:系统性审查和元分析
Huiru Li1, Jiang Yang1, Qionghua Xiao1
1National Regional TCM (lung disease) Diagnostic and Treatment Center, The First Affiliated Hospital of Henan University of TCM, Zhengzhou, China; First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, China.
Sleep medicine
|August 30, 2025
概括
大约三分之一的患者患有COPD- OSA重叠综合征,这种情况随着时间的推移而恶化. 定期查和干预对于管理这种普遍的呼吸系统疾病至关重要.
科学领域:
- 肺病学
- 睡眠医学
- 流行病学
背景情况:
- 慢性肺炎和OSA重叠综合征是一种普遍的疾病,与呼吸系统症状的增加,生活质量的降低和恶化风险的增加有关.
- 现有的COPD和OSA重叠综合征的流行率估计有很大差异,缺乏全球共识.
- 本综述提供了COPD和OSA重叠综合征的全球流行情况的全面概述.
研究的目的:
- 系统地审查和对COPD和OSA重叠综合征的全球流行情况进行元分析.
- 在研究中确定导致流行率估计异质性的因素.
主要方法:
- 在Embase,PubMed,Web of Science,Cochrane和Ovid Medline进行了系统的文献搜索,截至2025年2月24日.
- 使用R软件进行随机效应元分析,使用I2指数评估异质性.
- 使用敏感性,子组和元回归分析来探索异质性来源,并使用Begg测试来评估出版偏差.
主要成果:
- 这项分析包括了41项涉及1871071名参与者的研究,显示COPD- OSA重叠综合征的总流行率为28. 3% (95% CI: 20. 8-36. 4%).
- 在横截面研究 (30. 66%) 和亚洲 (37. 87%) 中,患病率较高.
- 在家庭睡眠呼吸暂停测试 (HSAT) 和多睡眠测试 (PSG) 中,患病率的估计是可比的,而在呼吸暂停- 低睡眠暂停指数 (AHI) 值≥5时,则较高. 研究期间,人口,样本大小和年龄影响了患病率.
结论:
- 大约三分之一的患者表现出COPD- OSA重叠综合征,随着时间的推移,患病率会增加.
- 根据人口,时间段,样本大小和年龄存在显著的流行病学变化.
- 建议定期对COPD或OSA进行查,并实施有效的治疗策略,以减轻不良健康结果.
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